Research progress on the establishment of animal models of amanitin poisoning

doi:10. 3969 / j.issn.1005-4847. 2023. 08. 014

Home > Archive>Volume 31, Issue 8, 2023 >1078-1084. DOI:10. 3969 / j.issn.1005-4847. 2023. 08. 014

Research progress on the establishment of animal models of amanitin poisoning
DOI:
                        10. 3969 / j.issn.1005-4847. 2023. 08. 014
                    
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Author:
                        ZHANG HuijieZHANG Huijie
NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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YANG GenmengYANG Genmeng
NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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WANG HaoweiWANG Haowei
NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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ZENG XiaofengZENG Xiaofeng
NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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LI ZhenLI Zhen
NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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Affiliation:NHC Key Laboratory of Drug Addiction Medicine/ Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China
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Abstract:

Mushroom poisoning is one of the most serious food safety problems in our country. More than 90% of deaths from mushroom poisoning are due to accidental ingestion of mushrooms containing amanitin. At present, many studies have focused on the toxicological mechanism, toxicokinetics, and treatment of amanitin poisoning, but comprehensive reviews on the establishment of animal models for various purposes are limited. Therefore, in accordance with the purpose and content of the experiment, this article reviews animal selection, types of poison and drugs, and injection method and doses to provide a theoretical basis and reference to establish animal models of amanitin poisoning.

Key words:amanitin; poisoning; animal model; toxicokinetic; poisoning treatment

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Received:March 08,2023
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Online: November 09,2023
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