Animal models of TCM are the experimental basis and necessary tools to conduct TCM research. Minipigs have stable genetic characteristics, a small size, easy breeding, docile nature, and similar physiology, biochemistry, and disease pathological manifestations to humans, which are ideal to establish experimental animal models and have broad application prospects and research value in the field of medicine. Researchers use small pigs to establish models of simple symptoms such as deficiency cold, blood stasis, actual heat, and spleen Qi deficiency. Models of atherosclerosis with spleen deficiency and phlegm turbidity and coronary heart disease with phlegm and phlegm stasis have achieved good result. However, the application of minipigs as TCM animal models is not widespread and worthy of further exploration.