Research progress on mouse models of diabetes macroangiopathy
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1.Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. 2. Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Chengdu 610075. 3. Shanghai Biotechnology Coporation, Shanghai 201203

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    Abstract:

    Animal models are widely used to study the pathogenesis of diseases and the safety, efficacy, and mechanisms of drug treatments. The selection and preparation of animal models that conform to the law of disease incidence are the basis and premise of experimental research. Diabetes macroangiopathy is characterized by extensive and rapidly progressing atherosclerosis of vascular walls. Mice are the most widely used experimental animals in atherosclerosis research. On the basis of the current research information and in accordance with the characteristics of type 1 and 2 diabetes, the development of diabetic atherosclerotic plaques, and the current monitoring technologies, this article systematically reviews diabetic atherosclerosis mouse models.

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History
  • Received:December 13,2022
  • Online: December 29,2023
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