Animal models are widely used to study the pathogenesis of diseases and the safety, efficacy, and mechanisms of drug treatments. The selection and preparation of animal models that conform to the law of disease incidence are the basis and premise of experimental research. Diabetes macroangiopathy is characterized by extensive and rapidly progressing atherosclerosis of vascular walls. Mice are the most widely used experimental animals in atherosclerosis research. On the basis of the current research information and in accordance with the characteristics of type 1 and 2 diabetes, the development of diabetic atherosclerotic plaques, and the current monitoring technologies, this article systematically reviews diabetic atherosclerosis mouse models.