Functional dyspepsia (FD) is a non-organic disease that is mainly due to regional dysfunction of the stomach and duodenum. In traditional Chinese medicine (TCM), it is classified as epigastric fullness and epigastric pain, and divided into the syndrome types of spleen deficiency and qi stagnation, spleen-stomach deficiency-cold (weak), spleen-stomach damp-heat, liver-stomach disharmony, and cold-heat complicated. TCM has a significant effect and high acceptance for treatment of FD, and the animal model with the combination of disease and syndrome is the basis and prerequisite for relevant research. Therefore, we organized and summarized the existing research on animal models of FD combined with disease and syndrome and explored the reasons for selection of specific modeling method and evaluation indicators. We identified the shortcomings of the current research to provide support for future research on animal models of FD combined with disease and syndrome.