Advances in animal models for albumin-related drug studies
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Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Biotechnology and Health Science, Wuyi University, Jiangmen 529000, China

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    Abstract:

    The main challenge of therapeutic peptides and proteins is their short plasma half-life due to rapid protease degradation. Drugs combining such peptides and proteins with albumin are defined as albumin-related drugs. Such a combination effectively prolongs their plasma half-life. Animal models are an important and indispensable tool to study drug pharmacokinetics. This review summarizes the two main animal models, rodents (wildtype mice, gene-modified mouse models, and rat models) and non-human primates (monkeys), and their development and application in albumin-related drugs. This review provides a reference for further studies on albumin-related drugs.

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History
  • Received:April 23,2023
  • Online: December 29,2023
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