The main challenge of therapeutic peptides and proteins is their short plasma half-life due to rapid protease degradation. Drugs combining such peptides and proteins with albumin are defined as albumin-related drugs. Such a combination effectively prolongs their plasma half-life. Animal models are an important and indispensable tool to study drug pharmacokinetics. This review summarizes the two main animal models, rodents (wildtype mice, gene-modified mouse models, and rat models) and non-human primates (monkeys), and their development and application in albumin-related drugs. This review provides a reference for further studies on albumin-related drugs.