Dilated cardiomyopathy is a main disease that causes heart failure and exhibits etiological heterogeneity. Nearly a quarter of dilated cardiomyopathy in patients is related to genetics, and ventricular dilation and myocardial systolic dysfunction are the main characteristics of the disease. LMNA mutation is a major cause of hereditary dilated cardiomyopathy, and arrhythmia is a major clinical manifestation of hereditary dilated cardiomyopathy with LMNA mutation. In recent years, establishment of a dilated cardiomyopathy model in C57/ B6 mice and its treatment by focused gene therapy has been a research focus, and some important conclusion have been drawn from the establishment of large animal models in dogs and pigs. However, large animals, especially non-human primates, are closer to humans. At present, dilated cardiomyopathy is not involved in the heart disease model of non-human primates. Therefore, this article reviews studies on rodent and large animal models of dilated cardiomyopathy at the genetic level and proposes the idea of developing a dilated cardiomyopathy model in a non-human primate. It also provides new ideas to study the pathogenesis and clinical treatment.