WANG Saifei
1.Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, ChinaXUN Jing
2.Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 300100WU Xueliang
3. the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000ZHANG Hui
2.Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 300100ZHANG Qi
2.Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 300100ZHANG Dapeng
2.Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 3001001.Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China. 2. Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin 300100. 3. the First Affiliated Hospital of Hebei North University, Zhangjiakou 075000
Natural killer (NK) cells as intrinsic immune cells kill tumor cells without the need for pre-stimulation by tumor antigens. Therefore, NK cell based immunotherapy has unique advantages and has made significant progress in tumor treatment. In this article, we review the development, classification, and mechanism of NK cells as well as the applications of NK cell based immunotherapies, including immune checkpoint inhibitors, adoptive cell therapy, and NK cell adapters in tumor immunity. Thus, we elucidate the principle, current status, and developmental trend of NK cellbased anti-tumor immunotherapies to provide ideas for their development and application in the field of tumor immunotherapy.
