Research progress of neurotransmitter detection technology in live brains

doi:10. 3969 / j.issn.1005-4847. 2023. 11. 013

Home > Archive>Volume 31, Issue 11, 2023 >1485-1497. DOI:10. 3969 / j.issn.1005-4847. 2023. 11. 013

Research progress of neurotransmitter detection technology in live brains
DOI:
                        10. 3969 / j.issn.1005-4847. 2023. 11. 013
                    
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Author:
                        ZHU Mingyu1,2ZHU Mingyu
1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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CUI Lili1CUI Lili
1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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CHEN Huan1CHEN Huan
1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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HOU Hongwei1HOU Hongwei
1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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HU Qingyuan1HU Qingyuan
1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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Affiliation:1. China National Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China. 2. Qingdao University, Qingdao 266071
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Abstract:

As endogenous chemical substances, neurotransmitters play a vital role in maintaining normal life activities. Abnormal levels of neurotransmitters can lead to physical, mental, and some neurodegenerative diseases. However, the ultralow concentration, complex chemical properties, and release modes of neurotransmitters make their accurate detection in vivo a great challenge. To accurately monitor neurotransmitters in the brain and accurately understand the release kinetics of neurotransmitters, we reviewed several method commonly used in the past five years to detect neurotransmitters in vivo and their research progress. The basic principle and applicability of microdialysis, electrochemical sensors, and fluorescence sensors are introduced in detail.

Key words:neurotransmitter; disease; detection; live body

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Received:May 24,2023
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Online: January 15,2024
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