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Home > Archive>Volume 32, Issue 4, 2024 >523-529. DOI:10. 3969 / j.issn.1005-4847. 2024. 04. 013
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Progress in animal models of hemophilic arthritis
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1. the Third Clinical School of Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China;2. Joint Center, the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510378, China;3. Guangdong Institute of Chinese Medicine and Orthopedics, Guangzhou 510378, China; 4. Department of Osteoporosis,the Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510378, China; 5. Regional TCM Hematology Treatment Center, the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510378, China; 6. the First Hospital of Jilin University, Changchun 130061, China

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    Abstract:

    Hemophilic arthritis (HA), caused by recurrent bleeding, can seriously affect patient quality of life and consumes extensive social and medical resources. There is thus a need to establish an animal model of HA for research; however, this is limited by ethical requirements. Here we review the recent literature and summarize research progress into animal models of HA at home and abroad, from the aspects of species selection, modeling method,histopathology, and imaging evaluation method. Species selection includes rodents such as mice, New Zealand rabbits, beagles, miniature pigs, and crab-eating macaques. Modeling method comprise gene knockout trauma models, gene knockout spontaneous models, and injection models. Among these, the gene knockout spontaneous model closely mimics the pathological process of spontaneous bleeding and concurrent arthritis in human HA, making it more relevant to human HA. However, due to high modeling costs, phenotypic instability, and low survival rates, this model is not the preferred choice for animal experimental studies. In contrast, gene knockout trauma models exhibit characteristics such as short modeling time, strong stability, and high success rates, thus being widely utilized in animal experimental research.Evaluation of HA models involves various imaging method including MRI, micro-CT, MSKUS / PD, in addition to various gross scoring method. By reviewing the progress of HA model research, more experimental evidence is provided for investigating the pathogenesis and validating the efficacy of HA treatments, thereby compensating for the lack of clinical data, particularly in the field of traditional Chinese medicine therapy.

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  • Received:June 09,2023
  • Online: June 11,2024
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