Alzheimer’s disease (AD) is a multifactorial degenerative disorder of the central nervous system that mainly manifests as cognitive dysfunction and loss of speech. In recent years, the zebrafish has attracted extensive attention because of its high homology with humans in terms of brain structure and function, nerve conduction, and pathogenic genes of AD. This article reviews the advantages of the zebrafish as an animal model of AD, covering topics in the pathogenesis of AD and the evaluation and screening of drugs for treatment of AD. The overall goal is to provide new insights into the pathogenesis of AD and development of novel drugs.