Advancements in application of the zebrafish model of Alzheimer’s disease
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1. the First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Outpatient Department, Eastern Theater General Hospital, Nanjing 210002, China; 3. Digestive Department,Jiangsu Provincial Hospital of Chinese Medicine, Nanjing 210004, China; 4. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; 5. College of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China; 6. Digestive Department, Eastern Theater General Hospital, Nanjing 210002, China

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    Abstract:

    Alzheimer’s disease (AD) is a multifactorial degenerative disorder of the central nervous system that mainly manifests as cognitive dysfunction and loss of speech. In recent years, the zebrafish has attracted extensive attention because of its high homology with humans in terms of brain structure and function, nerve conduction, and pathogenic genes of AD. This article reviews the advantages of the zebrafish as an animal model of AD, covering topics in the pathogenesis of AD and the evaluation and screening of drugs for treatment of AD. The overall goal is to provide new insights into the pathogenesis of AD and development of novel drugs.

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History
  • Received:August 09,2023
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  • Online: June 24,2024
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