With increased population aging, the incidence of osteoporosis (OP) increases year by year, and has become a key global public health problem. Its main characteristics are reduced bone mass and damage to bone microstructure, often clinically manifesting as pain, hunched-back posture, height reduction, and even bone fractures.Therefore, it is particularly important to actively carry out scientific research related to OP, and the construction of animal models has become one of the key drivers of medical research, especially for exploring new treatments and in drug development. Animal models that are a “combination of disease and syndrome”, integrating the characteristics of Chinese medicine, occupy an irreplaceable position in research aiming to modernize traditional Chinese medicines. On the basis of the current research status of disease-syndrome combination OP animal models, this paper summarizes model construction and evaluation method to provide certain ideas and references for research using these specialized OP animal models.