Audiogenic seizures (AGS) are the result of an epilepsy caused by strong acoustic stimulation and are characterized by generalized muscle spasms. AGS models are vital for studies of epileptogenesis, the search for causative genes and regulatory channels, and the screening of new antiepileptic drugs (AEDs). This paper summarizes the current progress of research on common animal models of AGS in terms of their pathogenetic features, possible pathogenesis, and causative genes to provide new research directions and targets for the development of AEDs.