Use of ferrets in nonclinical studies of anti-infective drugs

doi:10. 3969 / j.issn.1005-4847. 2024. 06. 013

Home > Archive>Volume 32, Issue 6, 2024 >799-818. DOI:10. 3969 / j.issn.1005-4847. 2024. 06. 013

Use of ferrets in nonclinical studies of anti-infective drugs
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                        10. 3969 / j.issn.1005-4847. 2024. 06. 013
                    
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Author:
                        LIU Xuewu1,2LIU Xuewu
1. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;2. Hunan Prima Drug Research Center Co. , Ltd. & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410329, China
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TANG Zining2TANG Zining
2. Hunan Prima Drug Research Center Co. , Ltd. & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410329, China
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PENG Dongdong2PENG Dongdong
2. Hunan Prima Drug Research Center Co. , Ltd. & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410329, China
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DU Yanhua1DU Yanhua
1. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China
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JIANG Dejian2JIANG Dejian
2. Hunan Prima Drug Research Center Co. , Ltd. & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410329, China
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Affiliation:1. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;2. Hunan Prima Drug Research Center Co. , Ltd. & Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410329, China
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Abstract:

Ferrets offer an advantage in nonclinical studies of anti-infective drugs because of their ability to be infected with and spread pathogenic microorganisms, especially viral strains, without the need for host adaptation.Additionally, the clinical symptoms exhibited by infected ferrets are very similar to those of humans. Although ferrets play a very important role in the research and development of antiviral drugs, the scope of their application remains limited. This may be related to the lack of corresponding national standards for laboratory animal feeding and application of ferrets as well as the lack of specific diagnostic and detection reagents. This paper summarizes the characteristics of ferrets as infectious disease models with a summary and analysis of the application direction of ferrets in anti-infective drug research. Our aim is to promote further standardization of the use of ferrets.

Key words:ferret; anti-infective drugs; standards; laboratory animal

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Received:September 20,2023
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Online: July 11,2024
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