Analysis of animal models of sequelae of pelvic inflammatory disease based on data mining
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1. the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China;2. Shandong University of Traditional Chinese Medicine, Jinan 250014, China

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    Abstract:

    Objective To review the characteristics of animal models of sequelae of pelvic inflammatory disease (SPID) to provide a reference for standardizing the modeling process and improving the modeling rate. Methods Literature relevant to animal models of SPID from the past 40 years was searched, and animal species, modeling method, modeling cycles, modeling substances, positive control drugs, and evaluation indexes were summarized and analyzed. Results A total of 243 study manuscripts were included, most of which induced the SPID model in rats via the phenol paste or microbial infection method. The modeling cycles were typically between 14 and 16 days, and the success of the models was mostly determined by pelvic tissue morphology observation and pathological HE staining. Few research reports have focused on the traditional Chinese medicine(TCM) disease combination model. Conclusions No consistent criteria have been established for SPID animal model modeling, and thus it is recommended that researchers evaluate changes to animal behavior, pelvic histomorphology, and pathology. TCM syndrome modeling lacks effective method and evaluation standards, which need further research and development. Finally, the selection and use of positive-control drugs need to be further explored and perfected.

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History
  • Received:March 01,2024
  • Online: August 26,2024
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