Advancements in research on the preventive and curative roles of glycyrrhetinic acid and its derivatives in neurodegenerative disease

doi:10. 3969 / j.issn.1005-4847. 2024. 07. 011

Home > Archive>Volume 32, Issue 7, 2024 >923-932. DOI:10. 3969 / j.issn.1005-4847. 2024. 07. 011

Advancements in research on the preventive and curative roles of glycyrrhetinic acid and its derivatives in neurodegenerative disease
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                        10. 3969 / j.issn.1005-4847. 2024. 07. 011
                    
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                        LIU Yixiao1LIU Yixiao
1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine,Jinan 250355, China
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HAN Xinyuan1HAN Xinyuan
1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine,Jinan 250355, China
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XIAO Yitong1XIAO Yitong
1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine,Jinan 250355, China
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YU Xinzhuo1YU Xinzhuo
1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine,Jinan 250355, China
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YE Tianyuan2YE Tianyuan
2. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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Affiliation:1. College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine,Jinan 250355, China; 2. Innovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
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Abstract:

The annual incidence of neurodegenerative disease has been increasing with the aging of the global population, seriously affecting the quality of life of elderly patients and imposing a heavy burden on society. Glycyrrhetinic acid, which inhibits neuroinflammation and protects neurons, is one of the main active ingredients of the traditional Chinese medicine Glycyrrhiza glabra. Increasing numbers of studies are focusing on the mechanism of action of glycyrrhetinic acid and its derivatives in neurodegenerative disease. This review summarizes studies on the effects and mechanisms of action of glycyrrhetinic acid and its derivatives in Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebellar atrophy. Additionally, the future applications of glycyrrhetinic acid and its derivatives in neurodegenerative disorders are discussed.

Key words:glycyrrhetinic acid; derivative; mechanism of action; neurodegenerative disease

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Received:December 22,2023
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Online: August 26,2024
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