Research progress on mechanism of necrotizing apoptosis in pancreatic disease
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1. Basic Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, China;2. Medical College of Yan’an University, Yan’an 716000, China; 3. Experimental Animal Center of Air Force military Medical University, Xi’an 710000, China

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    Abstract:

    Necroptosis is a regulated process of programmed cell death independent of aspartic acid-specific cysteine protease, which can induce inflammation. Studies have shown that necroptosis is closely related to the progression and prognosis of pancreatic disease and plays an important two-way regulatory role in its progression. Related necroptosis inhibitors and inducers are expected to be used in the treatment of pancreatic disease. We herein review the mechanism of necroptosis and its role in the progression of pancreatic disease to provide a new understanding of the pathogenesis and treatment of pancreatic diseases and offer a theoretical basis for the research and development of targeted drugs.

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History
  • Received:September 15,2023
  • Online: August 26,2024
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