Overview of behavioral evaluation Methods of Parkinson’s disease in rat and mouse and analysis of the characteristics of common animal models
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1. Henan University of Chinese Medicine, Zhengzhou 450046, China; 2. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou 450046, China

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    Abstract:

    Parkinson’s disease is the second most common neurodegenerative disease in middle-aged and elderly people. It is characterized by a long disease course and complex treatment process, introducing great challenges to society.Behavioral changes in animal models of Parkinson’ s disease can intuitively reflect the modeling situation of experimental animals and the effects of drug interventions. Therefore, selecting standardized animal models and appropriate behavioral assays is fundamental for both understanding the mechanisms of Parkinson’s disease and developing anti-Parkinson drugs.In this paper, we summarize the method of behavioral experiments of Parkinson’s disease using mice and rats at home and abroad and systematically summarize the experimental equipment, experimental method, evaluation indexes, and precautions of commonly used Parkinson’s behavioral experiments. We also provide an overview of the commonly used animal models of Parkinson’s disease and analyze their modeling mechanisms, alignment with the clinical features of Parkinson’s disease, and respective advantages and disadvantages. This analysis will help researchers in choosing appropriate animal models of Parkinson’s disease and behavioral testing method according to the purpose of the study.

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History
  • Received:November 23,2023
  • Online: August 26,2024
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