Huntington’ s disease ( HD) is an autosomal dominant neurodegenerative disease, with the main symptoms including chorea-like involuntary movements, psychiatric behavioral abnormalities, and cognitive impairment, which severely affect the lives of patients and consume extensive social and medical resources. Various experimental animal models of HD have been successfully established, to further our understanding of the pathological mechanisms and to explore treatment method of HD. This review outlines the establishment and application of various animal models, ranging from Caenorhabditis elegans, Drosophila melanogaster and zebrafish to mice, rats and miniature pigs, and analyzes the characteristics and advantages of the different models. By reviewing the different animal models and their relevant evaluation indicators, this article emphasizes the importance of utilizing a combination of multiple animal models to promote a deeper understanding of the disease mechanisms and develop effective treatment strategies.