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Home > Archive>Volume 32, Issue 8, 2024 >1084-1092. DOI:10. 3969 / j.issn.1005-4847. 2024. 08. 016
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Review of animal models of non-steroidal anti-inflammatory drug-induced gastric ulcer
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College of Acupuncture and Massage, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

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    Abstract:

    Gastric ulcer is a common digestive system disease, and the long-term use of non-steroidal antiinflammatory drugs (NSAIDs) is the second most important cause. NSAID-induced gastric ulcer animal models are key experimental tools for studying the pathogenesis, corresponding treatment method, and effective mechanisms of NSAIDinduced gastrointestinal injury. However, there are currently a lack of reviews on NSAID-induced gastric ulcer animal models. This review summarizes and compares the relevant literature on animal research into indomethacin- and aspirininduced gastric ulcers in the past 10 years, including the selection of experimental animals, drug solvents, and specific modeling method. The limitations of current models, such as the cumbersome modeling method, incomplete modeling details, inadequate models for clinical use, and lack of comparative drug research, are discussed. Feasible solutions are proposed with the aim of providing an effective reference for research in this field.

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History
  • Received:December 18,2023
  • Online: October 09,2024
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