Prostate cancer is a prevalent malignant tumor in the male genitourinary system, characterized by a high propensity for bone metastasis. It is a leading cause of mortality, with approximately 70% of deaths attributed to this form of metastasis. Mouse models provide a crucial tool in the investigation of prostate cancer bone metastasis, and play a pivotal role in elucidating the underlying pathophysiological mechanisms and in the development and assessment of therapeutic agents. In this review, we summarize research progress in the construction method and evaluation strategies used in establishing prostate cancer bone metastasis mouse models. Notably, this review focuses on the exploration of the mechanisms responsible for prostate cancer bone metastasis, using mouse models, with the aim of offering insights and serving as a valuable reference for prostate cancer bone metastasis.