Sick sinus syndrome (SSS) refers to damage to the sinoatrial node and its surrounding tissues, which leads to excitation and conduction dysfunction of the sinoatrial node, Results ing in arrhythmia diseases. A better understanding of the pathogenesis of SSS is required to provide a basis for its treatment, including establishing an animal model that can simulate human sinus node dysfunction. In this paper, we review the animal selection, the principles and method of modeling, and the evaluation method and detection indicators of the models, to provide a basis for further studies of the pathogenesis of SSS.