Advances in non-surgical animal models of vascular cognitive impairment

doi:10. 3969 / j.issn.1005-4847. 2024. 09. 014

Home > Archive>Volume 32, Issue 9, 2024 >1222-1232. DOI:10. 3969 / j.issn.1005-4847. 2024. 09. 014

Advances in non-surgical animal models of vascular cognitive impairment
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                        10. 3969 / j.issn.1005-4847. 2024. 09. 014
                    
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                        SUN Rong1SUN Rong
1. College of Acupuncture and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China
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MAO Zhongnan2MAO Zhongnan
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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ZHI Xiaodong2ZHI Xiaodong
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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SONG Xuexia2SONG Xuexia
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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SONG Xuexia2SONG Xuexia
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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ZHANG Shirui2ZHANG Shirui
2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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Affiliation:1. College of Acupuncture and Massage, Gansu University of Chinese Medicine, Lanzhou 730000, China; 2. Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730000, China
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Abstract:

Vascular cognitive impairment (VCI) includes a range of illnesses from mild cognitive impairment to dementia, attributable to cerebrovascular factors. Although appropriate animal models are needed to allow clinicopathological research and drug development, there are currently no animal models that can perfectly simulate the pathogenesis of VCI. At present, carotid artery and vertebral artery stenosis or occlusion are the main method for VCI modeling; however, increasing numbers of non-surgical method have recently emerged, providing new ideas and prospects for the study of this disease. In this paper, we consider the construction method, model mechanisms, and model characteristics of non-surgical animal models of VCI, to provide a reference to help researchers choose the most suitable animal model.

Key words:vascular cognitive impairment; non-surgical animal model; modeling method; model mechanism; model characteristics

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Received:April 17,2024
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Online: November 01,2024
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