Type 2 diabetes mellitus (T2DM) is a common metabolic disease characterized by hyperglycemia and insulin resistance. Peri-implantitis is a common complication of oral implants and is a frequent cause of implant restoration failure. In persistent hyperglycemia, T2DM patients are prone to peri-implant inflammation and aggravated bone destruction. An increasing proportion of T2DM patients with tooth loss choose oral implantation, and the probability of periimplant inflammation in such patients is increased. However, the pathogenesis and correlation between the conditions have not been the focus of in-depth studies. Rodent models can simulate T2DM and peri-implant inflammation and are widely used animal models of both diseases. Animal models of T2DM complicated with peri-implant inflammation are helpful for simulating the complex internal environment and further studying the pathologic progression, pathogenesis, interactions, and treatment. However, few such models have been constructed as yet. In this paper, we review rodent models of T2DM, periimplantitis, and T2DM combined with periimplantitis constructed in recent years, and their advantages and disadvantages, to provide a reference and help for relevant researchers.