Research progress in constructing animal models of steroid-induced osteonecrosis of the femoral head
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1.Henan University of Chinese Medicine, Zhengzhou 450046, China; 2.Zone One Department of Orthopedics and Traumatology, the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000, China

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    Abstract:

    As a complex and refractory disease, the incidence of steroid-induced osteonecrosis of the femoral head (SONFH) is increasing year by year and showing an increasing trend in younger people. A good animal model of disease can provide important support for studying the pathogenesis of SONFH and the development of treatment method . In this paper, the latest progress made in the construction of SONFH animal models is summarized and analyzed from the aspects of animal selection, modeling method , and model evaluation. To achieve this, we review and categorize the experimental studies related to SONFH animal models conducted in China and overseas in recent years, providing a reference for related research of SONFH.

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History
  • Received:January 22,2024
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  • Online: December 03,2024
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