Objective To establish a rat model of type 2 diabetes mellitus with hepatic fibrosis using a highlipid-sugar diet (HLSD) combined with inducement with carbon tetrachloride (CCl₄ ) and streptozotocin. Methods SD rats were randomly divided into a liver fibrosis (LF) group, type 2 diabetes combined with liver fibrosis (DLF) group, and normal group, with 10 rats in each group. All rats in the LF or DLE group were fed an HLSD for 4 weeks; then, all rats were intraperitoneally injected with 20% CCl₄ (once a week) according to body weight (5 mL/kg) to induce hepatic fibrosis for another 4 weeks. During CCl₄ treatment, rats in the DLF