Research progress of motor function evaluation Methods in animal models of sarcopenia

doi:10. 3969 / j.issn.1005-4847. 2025. 01. 012

Home > Archive>Volume 33, Issue 01, 2025 >117-126. DOI:10. 3969 / j.issn.1005-4847. 2025. 01. 012

Research progress of motor function evaluation Methods in animal models of sarcopenia
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                        10. 3969 / j.issn.1005-4847. 2025. 01. 012
                    
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Author:
                        YANG Sen1,2YANG Sen
1. Institute of Physical Education and Training, Capital University of Physical Education and Sports, Beijing 100191, China; 2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
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ZHANG Yong2ZHANG Yong
2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
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ZHOU Zhixiong3ZHOU Zhixiong
3. Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, Beijing 100191, China
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ZENG Ping4ZENG Ping
4. Health and Medical Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China
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Affiliation:1. Institute of Physical Education and Training, Capital University of Physical Education and Sports, Beijing 100191, China; 2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China; 3. Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, Beijing 100191, China;4. Health and Medical Department, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China
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Abstract:

Sarcopenia is an age-related skeletal muscle degenerative disease. Physiologically aging mice are the most commonly used animal model for studying sarcopenia. As sarcopenia is characterized by decreased skeletal muscle mass and reduced muscle strength, exercise performance as a reflection of muscle function is widely used to evaluate sarcopenia.Methods of evaluating the motor function of sarcopenia mouse models are generally designed based on muscle endurance, muscle strength, coordination, and balance. The method include tests such as treadmill exhaustion, voluntary wheel use, grip strength, horse grid, bars and balance beam tests. By collating recent publications, we have systematically summarized the method used for evaluating motor function, including the tests’ principles, procedures, evaluation indexes, advantages, and disadvantages. We then propose an operational program for evaluating the sarcopenia phenotype, which will be of help to researchers wishing to choose evaluation method appropriate to their specific research purposes. Further innovative technology for assessing motor function that could be instructive in the evaluation of skeletal muscle function and diagnosis of sarcopenia is summarized.

Key words:sarcopenia; mice; motor function assessment

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Received:August 28,2024
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Online: April 10,2025
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