Application status of the model organism zebrafish in radiation medicine research

doi:10. 3969 / j.issn.1005-4847. 2025. 01. 014

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Application status of the model organism zebrafish in radiation medicine research
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                        10. 3969 / j.issn.1005-4847. 2025. 01. 014
                    
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                        DONG Juancong1DONG Juancong
1. China Institute for Radiation Protection, Taiyuan 030006, China
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WANG Jingjie1WANG Jingjie
1. China Institute for Radiation Protection, Taiyuan 030006, China
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YU Jinhuan2YU Jinhuan
2. China-Korea (Changchun) International Cooperation Demonstration Zone Center for Disease Control and Prevention, Changchun 130051, China
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CHENG Jiao1CHENG Jiao
1. China Institute for Radiation Protection, Taiyuan 030006, China
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DANG Xuhong1DANG Xuhong
1. China Institute for Radiation Protection, Taiyuan 030006, China
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YANG Guodong3YANG Guodong
3. the 404 Company Limited, China National Nuclear Corporation, Jiayuguan 735100, China
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Affiliation:1. China Institute for Radiation Protection, Taiyuan 030006, China; 2. China-Korea (Changchun) International Cooperation Demonstration Zone Center for Disease Control and Prevention, Changchun 130051, China; 3. the 404 Company Limited, China National Nuclear Corporation, Jiayuguan 735100, China
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Abstract:

As a model organism that bridges the gap between cells and traditional mammals, the zebrafish has broad application prospects in radiation medicine research. Among its unique advantages are its characteristics of a high homology with human genes, high fertility, short embryonic period, and transparent and easy to observe embryos, making it an important tool in radiation medicine research. Recently, remarkable progress has been made in the application of zebrafish to investigate low-dose radiation biological effects, radiation therapy, and radiation damage prevention and treatment, key areas of radiation medicine. In this paper, these applications are reviewed; we explore the value of zebrafish in radiation medicine research and provide a reference for experimental research in related fields.

Key words:zebrafish; embryo; radiation medicine

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Received:May 11,2024
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Online: April 10,2025
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