Depression is a common mental illness that has a negative impact on patient quality of life, as well as representing a serious economic burden to society. The strategy of interfering with depression based on signaling pathways has recently attracted widespread attention. The cAMP pathway is an important cellular signaling pathway that plays a key role in the pathogenesis of and interventions for depression. In this review, we addresses recent studies on cAMP pathway-based interventions in depression, to provide a theoretical basis for regulating the cAMP pathway and its cascade mechanism in depression