Senile osteoporosis is a growing public health challenge with significant impacts on the daily life of the elderly population as a result of its hidden nature, high prevalence, and high risk of disability. Suitable animal models that simulate senile osteoporosis are crucial for understanding its pathological mechanism and to facilitate the development of anti-osteoporosis drugs and identify new therapeutic targets. This review considers the most commonly used method for creating animal models of senile osteoporosis, analyzes their advantages and limitations, and discusses research progress in animal models in terms of evaluation indicators, to provide references for research using animal models of senile osteoporosis.