Objective To explore the effects of camellia honey on intestinal inflammation and injury induced by a high-fat diet (HFD) in Drosophila. Methods A HFD model group of fruit flies was created by feeding with standard culture medium containing 30% lard. Each camellia honey groups were fed the same high-fat medium containing different concentrations of camellia honey. The body mass, eclosion rate, climbing ability, size of lipid droplets, and levels of intestinal reactive oxygen species in adult flies were measured and analyzed. Results Compared with the model group, each camellia honey groups showed significant improvements. Specifically, camellia honey ameliorated the following HFD-induced alterations: decline in eclosion rate, increase in pupal volume, increase in adult average body mass, decrease in adult climbing ability, enlargement of the lipid droplet area, elevation in intestinal ROS levels, and intestinal damage. Conclusions Camellia honey improved the growth and development, intestinal inflammation, and injury induced by a HFD in Drosophila.