Cancer-induced bone pain (CIBP) causes substantial suffering for cancer patients and also diminishes their quality of life and self-esteem. The mechanisms underlying CIBP are complex and evolve progressively with cancer advancement. Current treatment options show limited efficacy and are often accompanied by adverse effects. Traditional Chinese medicine demonstrates potential advantages in managing CIBP; however, the mechanisms of action remain poorly understood and require further investigation. The development of a standardized, stable, and reproducible animal model is crucial to advancing research on disease pathogenesis and verifying the effectiveness of therapeutic interventions. This review considers recent method for modeling CIBP in animals and summarizes the application of these models in studies of traditional Chinese medicine mechanisms, with the aim of guiding future research directions in CIBP.