Alzheimer’s disease (AD) is common neurodegenerative diseases that is the main causes of cognitive dysfunction and behavioral abnormalities. Constructing animal models with similar characteristics to human patients is crucial for advancing investigations of AD, and to develop new therapeutic drugs. Combined with the latest research progress, this review classifies animal models of AD according to aging models, genetically modified models, and chemically induced models. This review systematically summarizes the commonly used animal models of AD, and elucidates the modeling mechanisms and pathological changes, and compares their advantages and limitation, with a view to provide method ological references for researchers in selecting appropriate animal model for AD investigation.