Chronic obstructive pulmonary disease (COPD) is a common but preventable and treatable lung disease characterized by persistent airflow limitation. Comorbidities related to COPD have recently received widespread attention because of their serious effects on the quality of life and prognosis of patients, and their role in promoting the malignant development of COPD. Experimental animal models provide a key for studying the pathogenesis of COPD and its related comorbidities and for exploring effective treatment Methods. This review summarizes the modeling Methods and research progress into experimental animal models of COPD-related comorbidities, to provide references and guidance for future clinical research and screening of animal models of related comorbidities.