As one of the seven universal and five basic emotions, anger is a normal emotional response of the human body. When the external stimulation reaches certain thresholds, it affects both internal organs and psychology,which tends to induce a variety of unsettling changes. If the external stimulating factors are sudden, intense, and persistent, it may lead to systemic-potentially chronic-diseases. Animal models can simulate abnormal anger emotions of human beings caused by different inducements and can offer a basis for therapeutic studies of anger-related symptoms. Thus, these models provide important reference value for the treatment of diseases induced by anger,including aspects such as pathogenesis, drug development, and clinical efficacy evaluation. However, systematic research on the modeling method of anger is still lacking. Therefore, this article presents a review of the literature about anger expressed by aggressive behavior, the analysis included a combination of disease and syndrome in animal models and clinical research. The findings provide a reference for the design of anger-related models, mechanism research, and drug development.