Abstract:Alcoholic liver disease (ALD) has become one of the most important chronic liver diseases in China. In-depth studies of the pathogenesis and treatment strategies of ALD rely on the establishment of suitable animal models. This systematic review considers research progress in animal models of alcoholic liver disease,focusing on different construction method, the advantages and disadvantages and application value of commonly used animals, including rodents (such as the Lieber-De Carli, NIAAA/ Gao-Binge, and second strike models, et al) and zebrafish ( acute and chronic models), and briefly discusses emerging models such as miniature pigs and chicken embryos. This review thus aims to provide references for researchers to select suitable models, optimize existing models, and develop new animal models for alcoholic liver disease.