Research progress on rodent animal models for endometriosis
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1. Wuxi School of Medicine, Jiangnan University, Wuxi 214002, China; 2. Wuxi Maternal and Child Health Hospital, Wuxi 214002, China; 3. Wuxi Medical Center of Nanjing Medical University, Wuxi 214002, China

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    Abstract:

    Endometriosis(EMs) affects both physical and mental health in women of reproductive age, but no clinical cure exists. Suitable animal models are essential to better understand the pathogenesis of endometriosis and inform clinical treatment. Rodents are currently the preferred choice because of their low cost, well-defined reproductive cycles, and short modeling periods. Conventional rodent models of endometriosis include autologous,allogeneic, and xenogeneic transplantation models. Researchers have refined these models to more accurately replicate human disease states and clinical manifestations. This review summarizes the major types of rodent models for endometriosis, factors that influence model development, and criteria used to evaluate success rates. It also discusses future directions for animal model advancement.

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History
  • Received:April 01,2025
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  • Online: January 28,2026
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