Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a multifactorial etiology that poses considerable challenges to effective treatment. Traditional Chinese medicine (TCM) has demonstrated favorable therapeutic outcomes in the management of UC, and the development of disease-syndrome integrated animal models has emerged as a critical approach for bridging TCM and modern biomedical research. We systematically reviewed the main strategies for constructing UC animal models, with a specific focus on modeling protocols tailored to the TCM syndrome of large intestine damp-heat. These approaches encompass multifactorial induction pathways involving dietary, environmental, and microbial stimuli. In terms of model evaluation, emphasis was placed on integrating modern omics technologies, such as metabolomics and metagenomics, to enhance the objectivity and quantifiability of TCM syndrome identification in experimental models. We also summarize recent advances in the integration of geneedited models with damp-heat induction method, providing a conceptual framework for composite models that better simulate the complex interplay between UC pathogenesis and individual constitutional characteristics. These integrative models, supported by refined construction techniques and multidimensional evaluation systems, have the potential to improve scientific rigor and translational relevance, offering a robust experimental foundation for elucidating the mechanisms of TCM-based interventions in UC.