Subretinal fibrosis (SRFi) is a terminal pathological feature of blinding eye diseases such as agerelated macular degeneration, uveitis, and proliferative vitreoretinopathy, leading to a poor visual prognosis for patients. There are currently limited treatment options for SRFi, highlighting the need for further research into its mechanisms and the development of new therapies. Animal models have made recent progress as core tools for elucidating the pathological mechanisms of SRFi and developing treatment strategies. This review compares and analyzes the applicability of models using mice, rats, rabbits, pigs, and non-human primates in simulating the pathological features of SRFi. We summarize existing modeling strategies including laser photocoagulation, chemical injury, genetic engineering, and combined interventions. The current models, however, still have limitations in terms of their pathological reproducibility and time controllability, and there is thus a need to establish further standardized,highly reproducible models to promote the development of SRFi therapies and to overcome the bottlenecks in its treatment.