Objective :To observe the effects of rehabilitative training on cAMP and PKA expression, motor function in cerebral ischemia-reperfusion rats, for explore its mechanisms. Methods:The middle cerebral artery ischemia-reperfusion model was established by suture-embolus method in rats. 42 rats were randomly assigned to ischemia group, rehabilitative group and group. The changes of cAMP and PKA expression were determined by enzyme-linked immunosorbent assay (ELISA). Behavioral recovery was quantitated by scores. Results :（1）The expression of cAMP and PKA showed significant higher in rehabilitative group than the ischemia group.（2）The motor functional recovery of rehabilitative group was significantly better than the ischemia group . Conclusion: Rehabilitative training promote motor function recovery in cerebral ischemia-reperfusion rats that it was concerned with cAMP-protein kinase A signal pathway.