Objective ：To study the application of animal model of glaucoma and provide reference for the improvement of animal experimental methods and model. Methods Methods With“glaucoma ”and “animal models” as the main topics, literature related to animal models of glaucoma from 2012 to 2022 was collected from CNI and PubMed, and the species, gender, modeling methods and detection indexes of experimental animals were summarized, and the database was established for statistical analysis.Results A total of 400 articles conforming to the criteria were selected. Most of the experimental animals were C57BL / 6J mice, and most of them were male. Most of the modeling methods were anterior chamber injection induced type, transgenic type and laser photocoagulation induced type. The high frequency detection indicators mainly included intraocular pressure measurement, histopathology, western blot analysis and immunohistochemistry. Conclusions: at present, there are many methods to construct glaucoma animal models, but the intervention of related TCM factors is less. It is suggested to increase the glaucoma animal model combined with disease and syndrome. In this study, different animal models were evaluated by mining and analyzing the animal model experiments of glaucoma, and the mining contents provided references for the construction of animal models with high success rate of modeling, good reproducibility and high clinical coincidence, and provided ideas for the model improvement.