Objective Alzheimer's disease (AD) brings a huge burden to patients and society. As an important means of studying AD, animal experiments provide a lot of scientific basis for clinical and scientific researchers. This paper adopts the method of bibliometric analysis to reveal the research status, hotspots and trends in the field of AD animal experiments. Methods We obtained publications in the field of AD animal experiments from 2018 to 2022 from the Web of Science Core Collection (WoSCC) database. We use the analysis software CiteSpace 6.2.R2 (Advanced) to analyze the general information and keywords of publications in this field. Results After analyzing 4015 articles included in this study from 2018 to 2022, it was found that the annual publication volume of papers has gradually increased. In terms of the number of articles, the United States, the University of California System, Saito T, and the International Journal of Molecular Science are the countries, institutions, authors, and journals with the largest number of articles. "Alzheimer's disease" had the highest frequency of occurrence, and "anxiety" had the highest central degree. Conclusion This field focuses on the study of pathogenesis and treatment methods, and the plasticity of entorhinal cortex, neurons and synapses is a hotspot of current research. Future research trends may mainly focus on Aβ plaque formation, tau hyperphosphorylation, neurofibrillary tangle accumulation, glial inflammation, and ultimately loss of proper neuroplasticity. This article visually analyzes the hotspots and trends of AD animal experiments to help researchers understand the latest situation.