【Abstract】 Dilated cardiomyopathy is one of the main diseases causing heart failure, and there is etiological heterogeneity. Nearly 1/4 of the patients with dilated cardiomyopathy are related to genetics, and ventricular dilation and myocardial systolic dysfunction are the main characteristics of the disease.LMNA mutation is an important cause of hereditary dilated cardiomyopathy, and arrhythmia is an important clinical manifestation of hereditary dilated cardiomyopathy with LMNA mutation.In recent years, the construction and intervention of rodent dilated cardiomyopathy model based on the focused gene therapy of mice with C57/B6 genetic background has been a focus of research, and some important conclusions have been drawn from the construction of large animal models of dogs and pigs. However, large animals, especially non-human primates, are still more close to human models.At present, dilated cardiomyopathy is not involved in the heart disease model of non-human primates. Therefore, this paper reviews the studies on the rodent and large animal models of dilated cardiomyopathy at the genetic level, and also proposes the idea of developing a non-human primate dilated cardiomyopathy model based on the current research.It provides a new idea to study the pathogenesis and clinical treatment in the future.