Advances in animal models of intestinal fibrosis
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1.Nanjing University Of Chinese Medicine;2.Department of Gastroenterology, Jiangsu Provincial Hospital of Traditional Chinese Medicine

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Jiangsu Province Chinese medicine science and technology development plan youth talent project,Nanjing University of Chinese Medicine Luo Linxiu teacher development Fund project

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    Abstract:

    Intestinal fibrosis is a complication of inflammatory bowel disease, and its refractory and recurrent nature impose a serious disease burden on patients. The disease’s pathogenes is not clear, and there is no effective treatment. Moreover, there is still a lack of recognized intestinal fibrosis models. In this paper, we review the methods used to establish animal models of intestinal fibrosis both at home and abroad, and consider the clinical relevance, key characteristics, and advantages and disadvantages of the procedures. Intestinal fibrosis models were summarized according to the modeling period and methods.

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History
  • Received:August 09,2023
  • Revised:April 18,2024
  • Adopted:May 28,2024
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