Skin wounds are global public problems, especially in terms of the difficult healing of chronic wounds, which may seriously affect patients’ lives. Most skin-wound animal models are currently established by physical methods, and different animal models have different biological characteristics. This review therefore classifies mouse, rat, and other animal models of skin wounds according to the literature, summarizes and analyzes the construction of skin-wound animal models based on physical methods and evaluation indicators, and considers the advantages and disadvantages of different animal models, to provide a basis for the rational construction of skin-wound animal models and drug research and development.