The negative emotion of anger can have many effects on the body. The brain regions associated with the production of anger are mainly related to the central gray matter, amygdala, and hypothalamus. Animal models are an important tool for understanding diseases and mechanisms, and in recent years there has been a gradual increase in research on animal models of anger and the mechanisms of anger. Most studies on anger models have focused on the mid-suture dorsal nucleus, hypothalamus, and hippocampal regions, and related neurotransmitter studies have mainly been related to GABA expression and monoamine neurotransmitter content. The aim of this paper is to summarize the intracerebral neural mechanisms of anger onset by retrieving anger-related animal models, hoping to provide useful references for the study of angry emotions.