Overview of experimental methods for behavioral studies of Parkinson's disease in rats and mouse and commonly used animal models of Parkinson's disease
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Henan University of Traditional Chinese Medicine

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Qihuang Scholar (Letter of Teaching Traditional Chinese Medicine2022-6); Major public welfare projects in Henan Province(201300310100)

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    Abstract:

    Parkinson's disease is the second most common neurodegenerative disease in middle-aged and elderly people, with a long disease cycle and complex treatment process, which is a great challenge in today's society. Behavioral changes in animal models of Parkinson's disease can intuitively reflect the modeling situation of experimental animals and the changes after drug intervention. Therefore, the selection of standardized animal models and appropriate behavioral assays is the basis for Parkinson's disease mechanism research and anti-Parkinson's disease drug development. In this paper, we summarize the Parkinson's behavioral experimental methods in mice and rats at home and abroad, and systematically summarize the experimental equipment, experimental methods, evaluation indexes, and precautions of commonly used Parkinson's behavioral experiments, as well as provide an overview of the commonly used Parkinson's models, and analyze the modeling mechanism, the match with the clinical features of Parkinson's disease, and the advantages and disadvantages, which can help researchers choose the appropriate Parkinson's model according to the research purpose. It can help researchers to choose appropriate Parkinson's models and behavioral testing methods according to the purpose of the study, which is of some significance to the in-depth study of Parkinson's.

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History
  • Received:November 23,2023
  • Revised:April 01,2024
  • Adopted:June 18,2024
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