Gastric ulcer is a common digestive system disease, long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is the second most important cause of this disease. The NSAIDs-induced gastric ulcer animal models are the key to the experiments and are important for studying the pathogenesis, corresponding treatment methods, and effective mechanisms of NSAIDs-induced gastrointestinal injury. However, there is currently a lack of summary on the NSAIDs-induced gastric ulcer animal models. This review summarizes and compares the relevant literatures on animal researches on indomethacin and aspirin induced gastric ulcer in the past 10 years, including the selection of experimental animals, drug solvents, and specific modeling methods. It points out the limitations of current models, such as cumbersome modeling methods, incomplete modeling details, inadequate model fit for clinical use, and lack of comparative researches between drugs. Feasible solutions are proposed, aims to provide effective references for researches in this field.