Accompanied by the aggravation of global population aging, the incidence of neurodegenerative diseases has been increasing year by year, which seriously affects the quality of life of elderly patients and imposes a heavy burden on the society. Glycyrrhetinic acid is one of the main active ingredients of the traditional Chinese medicine Glycyrrhiza glabra, which inhibits neuroinflammation and protects neurons, etc. There is an increasing number of studies on the mechanism of action of glycyrrhetinic acid and its derivatives in neurodegenerative diseases. In this review, the studies on the effects and mechanisms of action of glycyrrhetinic acid and its derivatives in Alzheimer"s disease, Parkinson"s disease, amyotrophic lateral sclerosis, multiple sclerosis, and cerebellar atrophy are summarized, and on the basis of which, the future applications of glycyrrhetinic acid and its derivatives in neurodegenerative disorders are discussed and prospected.
Keyword:glycyrrhetinic acid;derivative;mechanism of action;neurodegenerative disease;progress of research