TGF-β1 is considered to be a key mediator in the formation of hepatic fibrosis, mainly by activating its downstream Smad signaling pathway. Smad2 and Smad3 are two major downstream regulators that promote TGF-β1-mediated tissue fibrosis, while Smad7 is a negative feedback regulator of the TGF-β1/Smad pathway and inhibits TGF-β1-mediated hepatic fibrosis. A growing number of studies have shown that natural products can delay the progression of HF by regulating the TGF-β1/Smad pathway, inhibiting HSC activation and reducing ECM deposition. This article reviews the molecular mechanism of TGF-β1/Smad signaling pathway in hepatic fibrosis, and summarizes the natural products that target the regulation of TGF-β1/Smad signaling pathway, in order to provide reference for the treatment of hepatic fibrosis.